"Genetic Engineering" Beatrice Mintz Hand Signed FDC Dated 1965 For Sale

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"Genetic Engineering" Beatrice Mintz Hand Signed FDC Dated 1965:
$999.99

Up for sale a VERY RARE! "Genetic Engineering" Beatrice Mintz Hand Signed First Day Cover Dated 1965. 

ES-6960

Beatrice Mintz (born

January 24, 1921 in New York has contributed to the understanding

of genetic modification, cellular differentiation and

cancer, particularly melanoma. Mintz was a pioneer of genetic

engineering techniques, and was among the first scientists to In 1996 she shared the

inaugural March of

Dimes Prize in Developmental Biology with Ralph L. Brinster for their work in developing transgenic

mice. Much of her career has been spent at the Fox Chase Cancer Center in

Philadelphia where, in 2002, she was named to the Jack Schultz Chair in Basic

Science. Mintz is a member of both the United

States National Academy of Sciences and the Pontifical Academy of

Sciences. Beatrice Mintz was born to Samuel and Janie Stein Mintz, a

Jewish family from Mikulintsy, Austria which was part of what was then called

Galicia. She graduated magna

cum laude from Hunter College in 1941 and then took graduate

studies at New York University for

a year. Because of anti Semitic admissions quotas in the colleges on the east

coast, she attended the University of Iowa where

she received a Master's degree in

1944 and a Ph.D. in 1946, studying amphibians under Emil Witschi. After graduation, Mintz

accepted a Professorship in Biological Science at the University of Chicago (1946–60; interrupted by studies

abroad: Mintz was awarded a Fulbright research fellowship at the universities

of Paris and Strasbourg in 1951). In 1960 she moved to the Institute

for Cancer Research of the Lankenau Hospital Research

Institute, which became the Fox Chase Cancer Center in

1974, where she remains on faculty. In the mid 1950s, Mintz switched her

research focus from amphibians to mammals and became a pioneer in

mammalian transgenesis. In 1965

she became an adjunct professor at the University of Pennsylvania.

Mintz and Kristoph Tarkowski independently made the first mouse embryonic

chimeras in the 1960s by aggregating two embryos at the eight-cell stage. The resultant mice developed normally

and their tissues were a mixture of cells derived from the two donor embryos. Mintz went on to create viable

chimeric embryos containing blastomeres from up to fifteen different laboratory mice. She developed a technique that

involved mixing cells from a black mouse strain into the blastocysts of white or brown mice in vitro. She then surgically transferred these early

embryos into surrogate mothers and, after birth, traced the tissue contribution

of each cell type made by studying the coat colour. Her cell fusion technique was

successful where others had failed due to the choice to remove the zona pellucida with pronase treatment, rather than physically. Since 1967

Mintz has created over 25,000 offspring using this technique.Mintz also

demonstrated could be reprogrammed to contribute to a healthy mouse when combined with

normal mouse embryo cells through eight years of experiments

utilizing some of the first pluripotent stem cell cultures

ever made. Mintz

and Rudolf Jaenisch published

a technological breakthrough in 1974. Jaenisch was a post-doctoral researcher

in Princeton University at

the time and was interested in why only certain types of cancer occurred when

he injected adult mice with viruses. Inspired by Mintz's earlier work, he

wanted to know whether injecting virus into early-stage embryos would result in

the DNA being incorporated, and what types of cancer would occur. Mintz

agreed to work with Jaenisch, who joined her lab as a visiting fellow for 9

months. They showed that DNA from a virus, SV40,

could be integrated into the DNA of developing mice and persist into adulthood

without apparent tumor formation. Although only somatic cells were affected,

meaning the DNA would not be passed on to future generations, these were the

first mice ever made with foreign DNA and this experiment proved healthy genetically modified

mammals could be created by viral infection. Using these

techniques Mintz was able to establish the genetic basis of certain kinds of

cancer and in 1993 she produced the first mouse model of human malignant melanoma. 

"Genetic Engineering" Beatrice Mintz Hand Signed FDC Dated 1965

$999.99

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