"Oral Contraceptive Pill” Gregory Pincus Hand Signed 3X5 Card For Sale
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"Oral Contraceptive Pill” Gregory Pincus Hand Signed 3X5 Card:
$699.99
Up for sale a VERY RARE! "Oral Contraceptive Pill." Gregory Pincus Hand Signed 3X5 Card.
ES-4080
Gregory Goodwin Pincus (April
9, 1903 – August 22, 1967) was an American biologist and researcher who
co-invented the combined oral
contraceptive pill.
Gregory
Goodwin Pincus was born in Woodbine, New Jersey, into
a Jewish family, the
son of Polish-Lithuanian-born immigrants Elizabeth (née Lipman) and Joseph
Pincus, an agriculture teacher.[2] He credited two uncles, both
agricultural scientists, for his interest in research. His IQ was said to be
210 and his family considered him a genius. Pincus
attended Cornell University and
received a bachelor's degree in agriculture in 1924. He attended Harvard University, where
he was an instructor in zoology while also working toward his master's and
doctorate degrees. From 1927 to 1930 he moved from Harvard to Cambridge University in
England to the Kaiser
Wilhelm Institute for Biology with Richard Goldschmidt in Berlin where he performed research. He became an
instructor in general physiology at Harvard University in
1930 and was promoted in 1931 to an assistant professor. Dr. Pincus began
studying hormonal biology and steroidal hormones early in his career. He was
interested in the way that hormones affected mammals' reproductive systems. His
first breakthrough came early, when he was able to produce in vitro fertilization in
rabbits in 1934. In 1936, he published his discoveries after his experiments.
His experiments involving parthenogenesis produced a rabbit that appeared on the
cover of Look magazine in 1937. To create the in vitro rabbit
baby, Pincus removed the ovum from the mother rabbit and placed it in a
solution mixture of saline and estrone. Afterwards, he placed the
"fertilized" ovum back into the rabbit. Pincus' experiment became
known as "Pincogenesis" because other scientists were unable to
attain the same results when conducting the experiment. After he was misquoted in an interview, it was believed that his experiment was
the beginning of the use of in vitro for humans. In
1944, Dr. Pincus co-founded the Worcester
Foundation for Experimental Biology in Shrewsbury, Massachusetts.
He wanted to continue his research of the relationship between hormones and
diseases such as, but not limited to, cancer, heart disease, and schizophrenia.
By the end of the 1960s, more than 300 international researchers came to
participate in the Worcester Foundation of Experimental Biology.
Pincus
never lost interest in mammals' reproduction systems. He began to research
infertility. In 1951, Margaret Sanger met Pincus at a dinner hosted by Abraham
Stone, director of the Margaret Sanger Research Bureau and medical director and
vice president of Planned
Parenthood Federation of America (PPFA), and procured a small
grant from PPFA for Pincus to begin hormonal contraceptive research. Pincus,
along with Min Chueh Chang, confirmed
earlier research that progesterone would
act as an inhibitor to ovulation. In 1952, Sanger told her friend Katharine McCormick about
Pincus and Chang's research. Frustrated by PPFA's meager interest and support,
McCormick and Sanger met with Pincus in 1953 to dramatically expand the scope
of the research with 50-fold increase in funding from McCormick. Pincus was
fascinated by Sanger because she revealed what life was like for women who were
living in poverty who endured many pregnancies. Sanger indirectly influenced
him to create a successful contraceptive to prevent unwanted pregnancies.
In
order to prove the safety of "the pill," human trials had to be
conducted. These were initiated on infertility patients of Dr. John Rock in Brookline, Massachusetts using
progesterone in 1953 and then three different progestins in 1954. Puerto Rico was selected as a trial site
in 1955, in part because there was an existing network of 67 birth
control clinics serving low-income women on the island. Trials began there in
1956 and were supervised by Dr. Edris Rice-Wray and Celso-Ramón García. Some
of the women experienced side effects from "the pill" (Enovid) and Edris
Rice-Wray wrote Pincus and reported that Enovid "gives one hundred
percent protection against pregnancy [but causes] too many side reactions to be
acceptable". Pincus and Rock disagreed based on their experience with
patients in Massachusetts and conducted research showing that placebos caused
similar side effects. The trials went on and were expanded to Haiti, Mexico and Los Angeles despite high attrition rates, due to the
large number of women eager to try this form of contraception. In May 1960, the
FDA extended Enovid's approved indications to include contraception.
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