"Oral Contraceptive Pill” Gregory Pincus Hand Signed 3X5 Card For Sale

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"Oral Contraceptive Pill” Gregory Pincus Hand Signed 3X5 Card:

Up for sale a VERY RARE! "Oral Contraceptive Pill." Gregory Pincus Hand Signed 3X5 Card. 


Gregory Goodwin Pincus (April

9, 1903 – August 22, 1967) was an American biologist and researcher who

co-invented the combined oral

contraceptive pill.


Goodwin Pincus was born in Woodbine, New Jersey, into

a Jewish family, the

son of Polish-Lithuanian-born immigrants Elizabeth (née Lipman) and Joseph

Pincus, an agriculture teacher.[2] He credited two uncles, both

agricultural scientists, for his interest in research. His IQ was said to be

210 and his family considered him a genius. Pincus

attended Cornell University and

received a bachelor's degree in agriculture in 1924. He attended Harvard University, where

he was an instructor in zoology while also working toward his master's and

doctorate degrees. From 1927 to 1930 he moved from Harvard to Cambridge University in

England to the Kaiser

Wilhelm Institute for Biology with Richard Goldschmidt in Berlin where he performed research. He became an

instructor in general physiology at Harvard University in

1930 and was promoted in 1931 to an assistant professor. Dr. Pincus began

studying hormonal biology and steroidal hormones early in his career. He was

interested in the way that hormones affected mammals' reproductive systems. His

first breakthrough came early, when he was able to produce in vitro fertilization in

rabbits in 1934. In 1936, he published his discoveries after his experiments.

His experiments involving parthenogenesis produced a rabbit that appeared on the

cover of Look magazine in 1937. To create the in vitro rabbit

baby, Pincus removed the ovum from the mother rabbit and placed it in a

solution mixture of saline and estrone. Afterwards, he placed the

"fertilized" ovum back into the rabbit. Pincus' experiment became

known as "Pincogenesis" because other scientists were unable to

attain the same results when conducting the experiment. After he was misquoted in an interview, it was believed that his experiment was

the beginning of the use of in vitro for humans. In

1944, Dr. Pincus co-founded the Worcester

Foundation for Experimental Biology in Shrewsbury, Massachusetts.

He wanted to continue his research of the relationship between hormones and

diseases such as, but not limited to, cancer, heart disease, and schizophrenia.

By the end of the 1960s, more than 300 international researchers came to

participate in the Worcester Foundation of Experimental Biology.


never lost interest in mammals' reproduction systems. He began to research

infertility. In 1951, Margaret Sanger met Pincus at a dinner hosted by Abraham

Stone, director of the Margaret Sanger Research Bureau and medical director and

vice president of Planned

Parenthood Federation of America (PPFA), and procured a small

grant from PPFA for Pincus to begin hormonal contraceptive research. Pincus,

along with Min Chueh Chang, confirmed

earlier research that progesterone would

act as an inhibitor to ovulation. In 1952, Sanger told her friend Katharine McCormick about

Pincus and Chang's research. Frustrated by PPFA's meager interest and support,

McCormick and Sanger met with Pincus in 1953 to dramatically expand the scope

of the research with 50-fold increase in funding from McCormick. Pincus was

fascinated by Sanger because she revealed what life was like for women who were

living in poverty who endured many pregnancies. Sanger indirectly influenced

him to create a successful contraceptive to prevent unwanted pregnancies.


order to prove the safety of "the pill," human trials had to be

conducted. These were initiated on infertility patients of Dr. John Rock in Brookline, Massachusetts using

progesterone in 1953 and then three different progestins in 1954. Puerto Rico was selected as a trial site

in 1955, in part because there was an existing network of 67 birth

control clinics serving low-income women on the island. Trials began there in

1956 and were supervised by Dr. Edris Rice-Wray and Celso-Ramón García. Some

of the women experienced side effects from "the pill" (Enovid) and Edris

Rice-Wray wrote Pincus and reported that Enovid "gives one hundred

percent protection against pregnancy [but causes] too many side reactions to be

acceptable". Pincus and Rock disagreed based on their experience with

patients in Massachusetts and conducted research showing that placebos caused

similar side effects. The trials went on and were expanded to Haiti, Mexico and Los Angeles despite high attrition rates, due to the

large number of women eager to try this form of contraception. In May 1960, the

FDA extended Enovid's approved indications to include contraception. 

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