Charles Huggins Autograph Nobel Prize Medicine Physiology Prostate Cancer #1 For Sale

Charles Huggins Autograph Nobel Prize Medicine Physiology Prostate Cancer #1


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Charles Huggins Autograph Nobel Prize Medicine Physiology Prostate Cancer #1:
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Charles B. Huggins - Autograph w/ Photo Nobel Prize Medicine 1966

 

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    Charles Brenton Huggins   From Wikipedia, the free encyclopedia   Charles Brenton Huggins Charles Brenton Huggins Born (1901-09-22)September 22, 1901
Halifax, Nova Scotia Died January 12, 1997(1997-01-12) (aged 95)
Chicago, Illinois Citizenship Canadian / American Fields physiology Institutions University of Michigan, University of Chicago Alma mater Acadia University
Harvard University Known for prostate cancer
hormones Notable awards Nobel Prize for Physiology or Medicine (1966)
Gairdner Foundation International Award (1966)

Charles Brenton Huggins (September 22, 1901 – January 12, 1997) was a Canadian-American physician, physiologist and cancer researcher at the University of Chicago specializing in prostate cancer. He was awarded the 1966 Nobel Prize for Physiology or Medicine for discovering in 1941 that hormones could be used to control the spread of some cancers.[1] This was the first discovery that showed that cancer could be controlled by chemicals.

 

Contents  [hide] 
  • 1 Early life and education
  • 2 Work
  • 3 References
  • 4 External links

 

Early life and education[edit]

Huggins was born in Halifax, Nova Scotia, Canada. He graduated from Acadia University with a BA degree in 1920. He went on to study medicine at Harvard University and received his MD degree in 1924. He served his internship and residency in general surgery with Frederick A. Coller at the University of Michigan.[2]

Work[edit]

Huggins established a method to measure the effect hormone changes have on prostatic function. He found out that castration or estrogen administration led to glandular atrophy, which could be reversed by re-administration of androgen. In 1941 the beneficial effect of androgen ablation on metastatic prostate cancer was realised when Huggins and Clarence Hodges treated patients by either castration or estrogen therapy. They monitored the prostate size and therapeutic efficacy by measuring serum Prostatic acid phosphatase levels and concluded that androgenic activity in the body influences prostate cancer, at least with respect to serum phosphatase. Huggins was the first to use a systemic approach to treat prostate cancer.

Huggins was awarded the Nobel Prize in Physiology or Medicine in 1966.[3]

Huggins died 1997 in Chicago, Illinois at the age of 95 years. His wife died in 1983.

References[edit]
  1. Jump up ^ Huggins C, Hodges CV (2002). "Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.". The Journal of Urology 167 (2): 948–951. doi:10.1097/00005392-200207000-00004. PMID 11905923. 
  2. Jump up ^ "Charles B. Huggins, MD, 1901-1997". University of Chicago Medicine 1997 Press Releases. University of Chicago. Retrieved 8 September 2015. 
  3. Jump up ^ Denmeade, SR; Isaacs, JT (May 2002). "A history of prostate cancer treatment.". Nature reviews. Cancer 2 (5): 389–96. doi:10.1038/nrc801. PMID 12044015. 
  • Toledo-Pereyra, L H (2001). "Discovery in surgical investigation: the essence of Charles Brenton Huggins". Journal of investigative surgery : the official journal of the Academy of Surgical Research 14 (5): 251–2. doi:10.1080/089419301753170011. PMID 11700917. 
  • Forster, R E (June 1999). "Charles Brenton Huggins (22 September 1901–12 January 1997)". Proceedings of the American Philosophical Society 143 (2): 325–31. PMID 11623829. 
  • Raju, T N (August 1999). "The Nobel chronicles. 1966: Francis Peyton Rous (1879–1970) and Charles Brenton Huggins (1901–97)". Lancet 354 (9177): 520. doi:10.1016/S0140-6736(05)75563-X. PMID 10465213. 
  • Schmähl, D (1980). "[Charles Brenton Huggins, Nobel Prize for Medicine 1966: "Discovery is our business"]". Chirurgisches Forum für experimentelle und klinische Forschung: VI–VIII. PMID 6993114. 
  • Drucker, W R (1973). "Charles B. Huggins, MD, FACS (hon)". Surgical forum 24: V. PMID 4618632. 
  • "Classics in oncology. Charles Brenton Huggins". CA: a cancer journal for clinicians 22 (4): 230–1. 1972. doi:10.3322/canjclin.22.4.230. PMID 4625048. 
  • Kenéz, J (October 1971). "[Ch. B. Huggins at the age of 70]". Orvosi hetilap 112 (42): 2535–7. PMID 4943846. 
  • Morii, S (May 1971). "[My professor, Dr. Huggins]". Hinyokika kiyo. Acta urologica Japonica 17 (5): 295–6. PMID 4933515. 
  • Fukunishi, R (October 1967). "[Pioneer of cancer research: Dr. Charles B. Huggins]". Nippon Rinsho 25 (8): 1709–12. PMID 4868962. 
  • Schmähl, D (December 1966). "[Charles Brenton Huggins]". Dtsch. Med. Wochenschr. 91 (51): 2308–9. PMID 5333371. 
  • Frenkel, M (November 1966). "[Charles Brenton Huggins, co-winner of the Nobel Prize in physiology and medicine, 1966]". Nederlands tijdschrift voor geneeskunde 110 (45): 1994–5. PMID 5342106. 
  • Luft, R (November 1966). "[Nobel prize in physiology and medicine 1966. Charles Brenton Huggins]". Nordisk medicin 76 (44): 1269–71. PMID 5337055. 
  • Franksson, C (October 1966). "[Nobel Prize of the year. II. Charles B. Huggins]". Lakartidningen 63 (43): 4102–4. PMID 5343069. 
  • TALALAY, P (June 1965). "The Scientific Contributions Of Charles Brenton Huggins". JAMA 192: 1137–40. doi:10.1001/jama.1965.03080260025007. PMID 14301033. 
External links[edit]
  • Nobel biography
  • Prostate Cancer
  • Ben May Department for Cancer Research
[hide]
  • v
  • t
  • e
Laureates of the Nobel Prize in Physiology or Medicine   1901–1925
  • 1901 Emil Behring
  • 1902 Ronald Ross
  • 1903 Niels Finsen
  • 1904 Ivan Pavlov
  • 1905 Robert Koch
  • 1906 Camillo Golgi / Santiago Ramón y Cajal
  • 1907 Alphonse Laveran
  • 1908 Élie Metchnikoff / Paul Ehrlich
  • 1909 Emil Kocher
  • 1910 Albrecht Kossel
  • 1911 Allvar Gullstrand
  • 1912 Alexis Carrel
  • 1913 Charles Richet
  • 1914 Róbert Bárány
  • 1915
  • 1916
  • 1917
  • 1918
  • 1919 Jules Bordet
  • 1920 August Krogh
  • 1921
  • 1922 Archibald Hill / Otto Meyerhof
  • 1923 Frederick Banting / John Macleod
  • 1924 Willem Einthoven
  • 1925
  1926–1950
  • 1926 Johannes Fibiger
  • 1927 Julius Wagner-Jauregg
  • 1928 Charles Nicolle
  • 1929 Christiaan Eijkman / Frederick Gowland Hopkins
  • 1930 Karl Landsteiner
  • 1931 Otto Warburg
  • 1932 Charles Scott Sherrington / Edgar Adrian
  • 1933 Thomas Morgan
  • 1934 George Whipple / George Minot / William Murphy
  • 1935 Hans Spemann
  • 1936 Henry Dale / Otto Loewi
  • 1937 Albert Szent-Györgyi
  • 1938 Corneille Heymans
  • 1939 Gerhard Domagk
  • 1940
  • 1941
  • 1942
  • 1943 Henrik Dam / Edward Doisy
  • 1944 Joseph Erlanger / Herbert Gasser
  • 1945 Alexander Fleming / Ernst Chain / Howard Florey
  • 1946 Hermann Muller
  • 1947 Carl Cori / Gerty Cori / Bernardo Houssay
  • 1948 Paul Müller
  • 1949 Walter Hess / António Egas Moniz
  • 1950 Edward Kendall / Tadeusz Reichstein / Philip Hench
  1951–1975
  • 1951 Max Theiler
  • 1952 Selman Waksman
  • 1953 Hans Krebs / Fritz Lipmann
  • 1954 John Enders / Thomas Weller / Frederick Robbins
  • 1955 Hugo Theorell
  • 1956 André Cournand / Werner Forssmann / Dickinson W. Richards
  • 1957 Daniel Bovet
  • 1958 George Beadle / Edward Tatum / Joshua Lederberg
  • 1959 Severo Ochoa / Arthur Kornberg
  • 1960 Frank Burnet / Peter Medawar
  • 1961 Georg von Békésy
  • 1962 Francis Crick / James Watson / Maurice Wilkins
  • 1963 John Eccles / Alan Hodgkin / Andrew Huxley
  • 1964 Konrad Bloch / Feodor Lynen
  • 1965 François Jacob / André Lwoff / Jacques Monod
  • 1966 Francis Rous / Charles B. Huggins
  • 1967 Ragnar Granit / Haldan Hartline / George Wald
  • 1968 Robert W. Holley / Har Khorana / Marshall Nirenberg
  • 1969 Max Delbrück / Alfred Hershey / Salvador Luria
  • 1970 Bernard Katz / Ulf von Euler / Julius Axelrod
  • 1971 Earl Sutherland Jr.
  • 1972 Gerald Edelman / Rodney Porter
  • 1973 Karl von Frisch / Konrad Lorenz / Nikolaas Tinbergen
  • 1974 Albert Claude / Christian de Duve / George Palade
  • 1975 David Baltimore / Renato Dulbecco / Howard Temin
  1976–2000
  • 1976 Baruch Blumberg / Daniel Gajdusek
  • 1977 Roger Guillemin / Andrew Schally / Rosalyn Yalow
  • 1978 Werner Arber / Daniel Nathans / Hamilton O. Smith
  • 1979 Allan Cormack / Godfrey Hounsfield
  • 1980 Baruj Benacerraf / Jean Dausset / George Snell
  • 1981 Roger Sperry / David H. Hubel / Torsten Wiesel
  • 1982 Sune Bergström / Bengt I. Samuelsson / John Vane
  • 1983 Barbara McClintock
  • 1984 Niels Jerne / Georges Köhler / César Milstein
  • 1985 Michael Brown / Joseph L. Goldstein
  • 1986 Stanley Cohen / Rita Levi-Montalcini
  • 1987 Susumu Tonegawa
  • 1988 James W. Black / Gertrude B. Elion / George H. Hitchings
  • 1989 J. Michael Bishop / Harold E. Varmus
  • 1990 Joseph Murray / E. Donnall Thomas
  • 1991 Erwin Neher / Bert Sakmann
  • 1992 Edmond Fischer / Edwin G. Krebs
  • 1993 Richard J. Roberts / Phillip Sharp
  • 1994 Alfred G. Gilman / Martin Rodbell
  • 1995 Edward B. Lewis / Christiane Nüsslein-Volhard / Eric F. Wieschaus
  • 1996 Peter C. Doherty / Rolf M. Zinkernagel
  • 1997 Stanley B. Prusiner
  • 1998 Robert F. Furchgott / Louis Ignarro / Ferid Murad
  • 1999 Günter Blobel
  • 2000 Arvid Carlsson / Paul Greengard / Eric Kandel
  2001–present
  • 2001 Leland H. Hartwell / Tim Hunt / Paul Nurse
  • 2002 Sydney Brenner / H. Robert Horvitz / John E. Sulston
  • 2003 Paul Lauterbur / Peter Mansfield
  • 2004 Richard Axel / Linda B. Buck
  • 2005 Barry Marshall / Robin Warren
  • 2006 Andrew Fire / Craig Mello
  • 2007 Mario Capecchi / Martin Evans / Oliver Smithies
  • 2008 Harald zur Hausen / Luc Montagnier / Françoise Barré-Sinoussi
  • 2009 Elizabeth Blackburn / Carol W. Greider / Jack W. Szostak
  • 2010 Robert G. Edwards
  • 2011 Bruce Beutler / Jules A. Hoffmann / Ralph M. Steinman (posthumously)
  • 2012 John B. Gurdon / Shinya Yamanaka
  • 2013 James Rothman / Randy Schekman / Thomas C. Südhof
  • 2014 John O'Keefe / May-Britt Moser / Edvard Moser
  • 2015 William C. Campbell / Satoshi Ōmura / Tu Youyou
  <img alt="" title="" width="1" height="1" style="border: none; position: absolute;" /> Retrieved from Categories:
  • 1901 births
  • 1997 deaths
  • Acadia University alumni
  • American Nobel laureates
  • American physiologists
  • Canadian physiologists
  • Canadian people of English descent
  • Canadian Nobel laureates
  • Harvard University alumni
  • Nobel laureates in Physiology or Medicine
  • People from Halifax, Nova Scotia
  • University of Chicago faculty
  • Canadian oncologists
  • 20th-century physicians
     

 


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