"Sickle Cell Anemia" Makio Murayama Hand Signed TLS Dated 1976 For Sale
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"Sickle Cell Anemia" Makio Murayama Hand Signed TLS Dated 1976:
$299.99
Up for sale "Sickle Cell Anemia" Makio Murayama Hand Signed TLS Dated 1976.
ES-4340
Biochemist best known for his work on
sickle cell anemia. Makio Murayama (1912–2012) was born in San Francisco, but
was sent to live with relatives at age age four upon the death of his father.
He was raised in Japan for the next ten years, returning to San Francisco when
he was fourteen. After graduating from Lowell High School in 1933, he went on
to the University of California where he graduated with bachelor's (1938) and
master's (1940) degrees in biochemistry and physics. With the outbreak of World
War II and the subsequent mass forced removal of Japanese Americans from the
West Coast, he was called to Chicago to work as a physicist on what would
become the Manhattan Project, while his family was sent to an American
concentration camp. But he was turned away because of his Japanese ancestry. He
eventually found a position as a blood chemist at the Children's Hospital of
Michigan and took similar positions at the Department of Pediatrics at the
University of Michigan and the Children's Pediatric Service at Bellevue
Hospital in New York over the next five years. He went on to finish his Ph.D.
in immunochemistry in 1953. He subsequently did postdoctoral work at the
California Institute of Technology working the Linus Pauling (1954–56) and at
the University of Pennsylvania (1956–58). In October of 1958, he joined the
staff of the National Institutes of Health in Bethesda, Maryland, where he
would work for the rest of his career. He engaged in landmark research on
sickle cell anemia, which had engaged his interest in Michigan where had worked
with child patients stricken with the disease. He famously built a three-foot
tall model of the hemoglobin molecule over a six-year period in his home
basement, using some 70,000 screws to represent atoms, which helped him gain a
clearer understanding of the disease and led to groundbreaking research on the
disease and a new treatment for it. He gained acclaim and fame for his work,
receiving the 1969 Association for Sickle Cell Anemia award and the 1972 Martin
Luther King, Jr. medical achievement award. He continued to work at NIH into
the 1980s. He died in Michigan on January 8, 2012.
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