"Sickle Cell Anemia" Makio Murayama Hand Signed TLS Dated 1976 For Sale


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"Sickle Cell Anemia" Makio Murayama Hand Signed TLS Dated 1976:
$299.99

Up for sale "Sickle Cell Anemia" Makio Murayama Hand Signed TLS Dated 1976. 


ES-4340

Biochemist best known for his work on

sickle cell anemia. Makio Murayama (1912–2012) was born in San Francisco, but

was sent to live with relatives at age age four upon the death of his father.

He was raised in Japan for the next ten years, returning to San Francisco when

he was fourteen. After graduating from Lowell High School in 1933, he went on

to the University of California where he graduated with bachelor's (1938) and

master's (1940) degrees in biochemistry and physics. With the outbreak of World

War II and the subsequent mass forced removal of Japanese Americans from the

West Coast, he was called to Chicago to work as a physicist on what would

become the Manhattan Project, while his family was sent to an American

concentration camp. But he was turned away because of his Japanese ancestry. He

eventually found a position as a blood chemist at the Children's Hospital of

Michigan and took similar positions at the Department of Pediatrics at the

University of Michigan and the Children's Pediatric Service at Bellevue

Hospital in New York over the next five years. He went on to finish his Ph.D.

in immunochemistry in 1953. He subsequently did postdoctoral work at the

California Institute of Technology working the Linus Pauling (1954–56) and at

the University of Pennsylvania (1956–58). In October of 1958, he joined the

staff of the National Institutes of Health in Bethesda, Maryland, where he

would work for the rest of his career. He engaged in landmark research on

sickle cell anemia, which had engaged his interest in Michigan where had worked

with child patients stricken with the disease. He famously built a three-foot

tall model of the hemoglobin molecule over a six-year period in his home

basement, using some 70,000 screws to represent atoms, which helped him gain a

clearer understanding of the disease and led to groundbreaking research on the

disease and a new treatment for it. He gained acclaim and fame for his work,

receiving the 1969 Association for Sickle Cell Anemia award and the 1972 Martin

Luther King, Jr. medical achievement award. He continued to work at NIH into

the 1980s. He died in Michigan on January 8, 2012. 



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