2 April 2007
Fungicide Causing Unusual Epigenetic Changes In Rats
by Kate Melville 
Epigenetic changes (inherited changes in gene regulation that occur without a change in DNA sequence) caused by a common fruit fungicide (Vinclozolin) are dramatically affecting the mating behavior of rats, say researchers from the University of Texas at Austin. They found that female rats avoid males whose great-grandfathers were exposed to the fungicide, preferring instead males whose ancestors were uncontaminated. Importantly, the researchers have shown that inherited epigenetic change can affect behavior and that environmental contamination could affect the evolution of wildlife through changes in mating behavior. The researchers, David Crews and Andrea Gore, examined mate preference in male and female rats whose great-grandparents were exposed to vinclozolin, which causes the early onset of cancer and kidney disease in males. They found that female rats could identify the male descendants of rats that had been exposed to vinclozolin. The females strongly preferred to associate with males who were descended from unexposed rats.
The study, appearing the Proceedings of the National Academy of Sciences, explains that vinclozolin causes changes in the male rats' germline cells (e.g. sperm), and while it does not directly alter DNA, it does causes changes in various elements that regulate genes. In the rats studied, the early onset of disease caused by initial exposure to vinclozolin was passed down from generation to generation through the germline of the males. "Even across generations, your attractiveness as a mate is decreased if your great-grandfather has been exposed to environmental chemicals," said Gore. "The female rats can sense something is wrong, although they can't see it. That will have an impact on your ability to reproduce and could take you out of the gene pool." "The important thing about this research is that it takes epigenetics to the brain," added Crews. "The female is able to detect which male is likely to get early onset disease and which male is not before they show any manifestation of disease. That has consequences for evolution, because it shows that females are selecting males on the basis of an epigenetic imprint as opposed to genetic changes." Related articles:
Inherited Disease Findings Stir Evolutionary Debate
Switching Genes On And Off To Cure Disease
Waterways Awash With Anti-Bacterial Chemical
Environmental Factors Damaging Men's Reproductive Health Source: University of Texas at Austin
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