Stem cells engineered to kill HIV

University of California – Los Angeles (UCLA) researchers have for the first time shown that human stem cells can be engineered into a genetic vaccine that can target and kill HIV-infected cells – a technique that could potentially be used against a number of other viral diseases. The researchers caution that the work to date, published in the journal PLoS ONE, is only preliminary and more must be done to ascertain whether the engineered cells would work in the human body.

“We have demonstrated in this proof-of-principle study that this type of approach can be used to engineer the human immune system, particularly the T-cell response, to specifically target HIV-infected cells,” said lead investigator Scott G. Kitchen. “These studies lay the foundation for further therapeutic development that involves restoring damaged or defective immune responses toward a variety of viruses that cause chronic disease, or even different types of tumors.”

The researchers took CD8 cytotoxic T lymphocytes (“killer” T cells that help fight infection) from an HIV-infected individual and identified the molecule known as the T-cell receptor, which guides the T cell in recognizing and killing HIV-infected cells. These cells, while able to destroy HIV-infected cells, do not exist in large enough numbers to clear the virus from the body. So the researchers cloned the receptor and genetically engineered human blood stem cells, then placed the stem cells into human thymus tissue that had been implanted in mice, allowing them to study the reaction in a living organism.

Promisingly, the engineered stem cells developed into a large population of mature, multifunctional HIV-specific CD8 cells that could specifically target cells containing HIV proteins. The researchers also found that HIV-specific T-cell receptors have to be matched to an individual in much the same way that an organ is matched to a transplant patient.

The research team said the next step is to test this strategy in a more advanced model to determine if it would work in the human body. They also hope to expand the range of viruses against which this approach could be used. “This approach could be used to combat a variety of chronic viral diseases,” said co-researcher Jerome A. Zack. “It’s like a genetic vaccine.”

Related:
Novel Antibody Tackles HIV’s Achilles Heel
HIV’s Virulence An Evolutionary Accident
Combination approach could eradicate HIV from body
Compelling new evidence for benefits of circumcision

Source: University of California – Los Angeles

, ,

Comments are closed.

SIGNED DR. ANTHONY FAUCI FDC AUTO FIRST DAY COVER - HIV/AIDS - COVID 19 picture

SIGNED DR. ANTHONY FAUCI FDC AUTO FIRST DAY COVER - HIV/AIDS - COVID 19

$49.99



Dr Anthony Fauci signed autographed 3x5 index card COVID-19 Ebola HIV/AIDS picture

Dr Anthony Fauci signed autographed 3x5 index card COVID-19 Ebola HIV/AIDS

$20.00



Dr Anthony Fauci signed autographed PHOTO COVID-19 Ebola HIV/AIDS picture

Dr Anthony Fauci signed autographed PHOTO COVID-19 Ebola HIV/AIDS

$24.95



AIDS poster Netherlands lesbian gay homosexual queer safe sex HIV cause picture

AIDS poster Netherlands lesbian gay homosexual queer safe sex HIV cause

$25.00



Bush AIDS flag postcard HIV ACT UP George H.W. gay lesbian protest cause skull picture

Bush AIDS flag postcard HIV ACT UP George H.W. gay lesbian protest cause skull

$15.00



AIDS Memorial Day poster Amsterdam 1994 HIV gay lesbian homosexual cause picture

AIDS Memorial Day poster Amsterdam 1994 HIV gay lesbian homosexual cause

$40.00



Dr Anthony Fauci signed autographed bookplate COVID-19 Ebola HIV/AIDS picture

Dr Anthony Fauci signed autographed bookplate COVID-19 Ebola HIV/AIDS

$24.95



AIDS poster safe sex HIV condom Netherlands gay homosexual queer coffin cause picture

AIDS poster safe sex HIV condom Netherlands gay homosexual queer coffin cause

$25.00



Zimbabwe Silver Gold Bar COA Box Old Zebra Rhino Stamps Case Africa Hut HIV Aids picture

Zimbabwe Silver Gold Bar COA Box Old Zebra Rhino Stamps Case Africa Hut HIV Aids

$75.75



RARE

RARE "HIV Discoverer" Robert Gallo Signed TLS Dated 1995

$399.99



Powered by WordPress. Designed by WooThemes