Pharmacologists Confirm Chemo’s Brain Damaging Effects

The latest issue of Pharmacology, Biochemistry and Behavior confirms what many chemotherapy patients have long suspected; chemotherapy addles the brain. Led by Dr. Gordon Winocur, of the Baycrest Research Centre for Aging and the Brain, the new study confirmed that “chemobrain” is indeed a real side-effect of the treatment, causing a decline in memory and other cognitive functions.

Previous studies have produced mixed results in confirming chemobrain’s existence. Dr. Winocur cited small samples, less than adequate controls and failure to account for other factors, as the main issues. In the new study, healthy female mice received standard doses of methotrexate and 5-fluorouracil, two drugs widely used to prevent the recurrence of breast cancer. A control group of mice received a saline solution.

After three weeks, the mice were put through a series of spatial/non-spatial memory tests and conditional rule learning tests in a water maze. The drug treatment group scored lower on the spatial memory task (hippocampus) and the task requiring strategic and working memory components (frontal lobes).

Tellingly, the drug group was not impaired on a cued memory test or in discrimination learning, tasks that are not affected by selective damage to the frontal lobes or hippocampus.

“This indicates that the adverse effects of this treatment regimen of methotrexate and 5FU probably do not extend to all regions of the brain. It appears that the hippocampus and frontal lobes are primarily affected,” said Dr. Winocur. He quantified the learning and memory deficits related to treatment as being in the mild to moderate range. “That the deficits were relatively small is encouraging. It’s important that cancer patients know that if they experience mild to moderate impairments in their cognitive functions, this level of change is potentially manageable.” Dr. Winocur noted that the study assessed only the short-term effects of the drugs and there was a possibility there might have been some recovery of cognitive function over time.

Source: Baycrest Research Centre for Aging and the Brain

, ,

Comments are closed.

73 Carat Unusual Natural Both Side Trapiche Corundum Crystal Six ray Star Effect picture

73 Carat Unusual Natural Both Side Trapiche Corundum Crystal Six ray Star Effect

$399.99



Raised Pink Flowers on cover and sides of this pretty little Trinket Box - MINT picture

Raised Pink Flowers on cover and sides of this pretty little Trinket Box - MINT

$17.32



Small Pink Vase Cabo  Sculpted Flowers On Side  picture

Small Pink Vase Cabo Sculpted Flowers On Side

$11.50



Vintage Double Sided Santa Candle Holder - Made In Japan picture

Vintage Double Sided Santa Candle Holder - Made In Japan

$21.95



1994 Press Photo Marijuana Medical side effects - dfpb93489 picture

1994 Press Photo Marijuana Medical side effects - dfpb93489

$10.00



SIDE EFFECTS 11.5x17 PROMO MOVIE POSTER picture

SIDE EFFECTS 11.5x17 PROMO MOVIE POSTER

$4.10



BROWNING BLACK LABEL -SIDE EFFECTS KNIFE picture

BROWNING BLACK LABEL -SIDE EFFECTS KNIFE

$15.00



Star Wars CCG Special Edition DARK SIDE Common/Uncommons | Characters & Effects picture

Star Wars CCG Special Edition DARK SIDE Common/Uncommons | Characters & Effects

$0.99



Lot/Pair Antique Paris Spill Vases - White/Gold Accents Flower Porcelain  U PICK picture

Lot/Pair Antique Paris Spill Vases - White/Gold Accents Flower Porcelain U PICK

$39.99



2005 Heartwood Creek Jim Shore Santa Figurine He Knows 4002405 Two Sided picture

2005 Heartwood Creek Jim Shore Santa Figurine He Knows 4002405 Two Sided

$52.10



Powered by WordPress. Designed by WooThemes