Human Genome “Far More Complex Than Anyone Imagined,” Lament Researchers

It looks like it may be back to the drawing board for many of the new gene therapy treatments being developed around the world. Professor Alexandre Reymond, from the Centre for Integrative Genomics in Switzerland, told attendees at the annual conference of the European Society of Human Genetics that current gene knock-out and knock-in models may be invalid due to huge gaps in the map of the human genome.

Reymond is part of an international team (known as the ENCODE consortium) working toward identifying all the functional elements in the human genome sequence. The pilot phase is focusing on 44 regions, totaling approximately 1 percent of the human genome. By testing and comparing existing methods for annotating the human genome, the consortium members hope to find the most effective ways of analyzing it in its entirety.

While Reymond acknowledged that the “finished” sequence of the human genome announced in 2003 was a great achievement, he noted that it left a number of questions unanswered; specifically, the identity and precise location of all the protein-encoding and non protein-encoding genes in the genome. “We found that the vast majority of the protein coding genes we studied utilized previously unknown exons [the regions of DNA within a gene that are transcribed to messenger RNA] outside the current boundaries of the annotated genes,” Reymond said.

“The notion that mammalian transcriptomes [the set of all messenger RNA molecules produced in a population of cells] are made of a swarming mass of different overlapping transcripts, together with our findings that suggest we have only uncovered a portion of its complexity, has important implications for medicine, explained Reymond. “They increase the size of the genomic regions that might harbor disease-causing mutations, and they could impair cloning strategies that try to find genes implicated in these pathologies.”

Reymond urged that extra caution should be used by medical researchers when associating a genetic phenotype with a gene knock-out or knock-in model (where genes are added or deleted from a model organism in order to study the effect of therapies). “It appears that the same nucleotide [the structural unit of DNA and RNA] on the genome can carry out a number of different, sometimes simultaneous, functions. Our work has shown that the human genome is far more complex than anyone could have imagined, even ten years ago. Understanding these complexities is essential to the development of effective and safe genetic medicine in the future,” he concluded.

Related articles:
DNA Structure Still Surprises
Personality Encoded In Junk DNA
Horizontal Gene Transfer Accelerating Evolution
Junk RNA Begins To Yield Its Secrets
Biochemists Mull Alternative DNA Structures

Source: European Society of Human Genetics

, , ,

Comments are closed.

Stuyvesant High 1974 YEARBOOK ERIC LANDER HUMAN GENOME PROJ FRANK MCCOURT SIGNED picture

Stuyvesant High 1974 YEARBOOK ERIC LANDER HUMAN GENOME PROJ FRANK MCCOURT SIGNED

$225.24



B5550- 2011 American Pie History #s 1-200 +Inserts -You Pick- 15+ FREE US SHIP picture

B5550- 2011 American Pie History #s 1-200 +Inserts -You Pick- 15+ FREE US SHIP

$1.99



The Human Genome Project Educational Kit from NIH (1980s) VHS, CD, booklet picture

The Human Genome Project Educational Kit from NIH (1980s) VHS, CD, booklet

$7.99



J. Craig Venter Human Genome Biochemist Rare Signed Autograph Photo Display picture

J. Craig Venter Human Genome Biochemist Rare Signed Autograph Photo Display

$69.99



Human Genome Project 2008 Historical Moments Upper Deck Card #194 (NM) picture

Human Genome Project 2008 Historical Moments Upper Deck Card #194 (NM)

$2.95



2011 Topps American Pie Human Genome Project #185 2k3 picture

2011 Topps American Pie Human Genome Project #185 2k3

$1.40



2011 Topps American Pie Human Genome Project #185 Spotlight Foil 11/76 SP. Rare picture

2011 Topps American Pie Human Genome Project #185 Spotlight Foil 11/76 SP. Rare

$249.95



VENTER, J. CRAIG SIGNED CARD, BIOLOGIST, HUMAN GENOME, BIOTECHNOLOGIST, BUSINESS picture

VENTER, J. CRAIG SIGNED CARD, BIOLOGIST, HUMAN GENOME, BIOTECHNOLOGIST, BUSINESS

$65.00



RARE

RARE "Human Genome Pioneer" Robert L. Sinsheimer Signed 3X5 Card

$499.99



Nakano Human Genome Live Report Badge Lot of 8 Graph Art Manga Character Goods picture

Nakano Human Genome Live Report Badge Lot of 8 Graph Art Manga Character Goods

$94.76



Powered by WordPress. Designed by WooThemes