Obesity and infertility linked across generations

The hormonal changes which are triggered by obesity can “program” the reproductive systems of the female offspring of obese women and lead to infertility, report endocrinologists in the journal Endocrinology.

Hormones involved in energy balance and metabolism have been shown to regulate reproductive function in animals and humans. Levels of one of these hormones – ghrelin – are low in obese women, so study author Hugh Taylor decided to examine the effect of ghrelin deficiency on the developmental programming of female fertility.

Taylor and his Yale co-researchers observed that female mice born of mice with ghrelin deficiency had diminished fertility and produced smaller litters than mice born of mice with normal ghrelin levels. Additionally, mice exposed to ghrelin deficiency in-utero demonstrated alterations in uterine gene expression which lead to impaired embryo implantation and consequently low fertility.

Ghrelin’s role in reproductive tract development remains unclear but Taylor believes the findings have significant implications for women. “Our results suggest that low ghrelin levels could program the development of the uterus in the female children of obese women. These women may then be less fertile as adults,” he concluded.

Related:
Obesity to affect at least 42 percent of adults, say Harvard researchers
Low birth weight infants “programmed” for obesity
More evidence for obesity-infertility link

Source: The Endocrine Society

, ,

Comments are closed.

Saint Charles Borromeo Catholic Medal, Patron of Obesity and Dieting #2 picture

Saint Charles Borromeo Catholic Medal, Patron of Obesity and Dieting #2

$3.99



Bumper Sticker Decal - I'm Fat, Let's Party - Obesity, Overweight, BBW picture

Bumper Sticker Decal - I'm Fat, Let's Party - Obesity, Overweight, BBW

$6.99



c1903 photograph of

c1903 photograph of "Big Joe" - the largest man in the world Summary: Obese man

$14.99



Photo: Photograph, men, obesity, people, body type, clothing, New York, NY, Paul picture

Photo: Photograph, men, obesity, people, body type, clothing, New York, NY, Paul

$14.99



1978 Press Photo Richard Lampman Obesity Michigan - dfpb66327 picture

1978 Press Photo Richard Lampman Obesity Michigan - dfpb66327

$10.00



MISC Old Bawdy Comic Funny Cartoon Postcard Cowboy Obese Fat Woman Donkey Ass  picture

MISC Old Bawdy Comic Funny Cartoon Postcard Cowboy Obese Fat Woman Donkey Ass

$1.99



Holy Prayer Card St Charles Borromeo Obesity & Dieting Medal Laminated picture

Holy Prayer Card St Charles Borromeo Obesity & Dieting Medal Laminated

$7.99



Vintage 1909 Howard Obesity Ointment The Howard Company Original Ad 721 picture

Vintage 1909 Howard Obesity Ointment The Howard Company Original Ad 721

$6.29



1900's Ad To Fat People Obesity Its Cause & Cure Henry C Bradford MD 23rd St NY picture

1900's Ad To Fat People Obesity Its Cause & Cure Henry C Bradford MD 23rd St NY

$19.50



1900s 1903 Ad To Fat People Book Obesity Its Cause & Cure Henry C Bradford MD NY picture

1900s 1903 Ad To Fat People Book Obesity Its Cause & Cure Henry C Bradford MD NY

$19.50



Powered by WordPress. Designed by WooThemes