What exnihilo is saying appears to be quoted from the Encyclopaedia of Creation Science.

http://creationwiki.org/%28Talk.Origins%29_Most_mutations_are_harmful

That would explain his re-writing factual knowledge of simple, basic cellular biology in accordance with religious belief, and his ignorance of bountiful evidence of Darwinian evolution to the extent of denying any evidence whatsoever. There's nothing to be gained by attempting to feed a creationist with facts, nor by referring them to excellent books like:

'The Making of the Fittest: DNA and the ultimate forensic record of evolution', by Sean B. Carroll.

Meanwhile, creationist educators continue to try to remake the world in the image of their delusions.

Claim CB101: Most mutations are harmful, so the overall effect of mutations is harmful.

http://www.talkorigins.org/indexcc/CB/CB101.html

Incidentally, Holt, Rinehart and Winston is a publishing subsidiary (for grades 6–12) of Harcourt Education, based in...Austin, Texas.