RARE “Protein Biophysics Pioneer" Harold Scheraga Hand Signed FDC Dated 1963 For Sale

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RARE “Protein Biophysics Pioneer" Harold Scheraga Hand Signed FDC Dated 1963:
$499.99

Up For sale "Hydrophobic Effect" Harold Scheraga Hand Signed First Day Cover Dated 1963. 

ES-3225

Harold Scheraga (born

October 18, 1921) is an American biophysicist, currently the George W. and Grace L. Todd

Professor Emeritus in the chemistry department at Cornell University. Scheraga

is regarded as a pioneer in protein biophysics and has been

especially influential in the study of protein solvation and the hydrophobic effect as

it relates to protein folding. Scheraga

was born in 1921 in Brooklyn, New York and

spent his early life in Monticello, New York. His

father worked as a machinist and opened a business

there. The family returned to Brooklyn in 1929 due to business losses following

the 1929 Wall Street Crash and

struggled economically through the Great Depression. As a high school student, Scheraga was

interested in mathematics and especially in classics, which he intended to pursue in college, but exposure

to physics during his education at the City College of New York convinced

him to focus on physical chemistry. He received his bachelor's degree from

CCNY in 1941 and his Ph.D. from Duke University in 1946. During his graduate work, he

spent time on projects related to the US war effort in World War II as well as on his own research. While at

Duke he worked with Fritz London, Paul Gross, and others. After graduation, he spent a year

as a postdoctoral fellow at Harvard Medical School with John Edsall, where he first began to work with proteins. Scheraga

has spent his entire academic career at Cornell University,

beginning with an appointment as an instructor in 1947, becoming an associate professor in

1950, and eventually being promoted to full professor in 1958. As he later recalled, he was

offered the instructor appointment by Peter Debye on the same day as his interview. He

became the Todd Professor of Chemistry in 1965 and retired, assuming emeritus status, in 1992. Scheraga served as the

department chair from 1960-67. Throughout his faculty career, Scheraga taught

undergraduate courses in physical chemistry, as

well as graduate courses focused more specifically on proteins. Scheraga's

research career has focused on protein biophysics, beginning in the 1940s when

little was known about the subject. His work on protein solvation, the hydrophobic effect, and

the consequences for protein folding was controversial in its early stages,

but has been highly influential. He has also been a significant contributor in

theoretical and computational biophysics, developing statistical mechanical models

for the hydrophobic effect and playing a key role in early molecular mechanics models

of proteins, developing force fields for use

in protein and peptide simulations. Most of his more recent work has focused

on molecular dynamics simulations

of proteins and protein folding, particularly as compared to NMR measurements. Scheraga

met his wife Miriam Kernow, at the time a sociology student at Brooklyn College, through a Jewish social club in Brooklyn in

which he participated during his time as a CCNY student. They married while

Scheraga was at Duke, where Miriam briefly took a technician job in analytical

chemistry to support the couple. She later worked in the Cornell University

library. They have three children. 

RARE “Protein Biophysics Pioneer" Harold Scheraga Hand Signed FDC From 1963

$499.99

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