Antihistamines may be next blockbuster anti-cancer drug

Scientists have established a connection between two diseases that aren’t commonly linked: allergy and cancer. The new research, published in the The Journal of Leukocyte Biology, shows that antihistamines appear to have “significant” anti-cancer properties. Specifically, antihistamines were found to interfere with the activity of myeloid derived suppressor cells, which are known to reduce the body’s ability to fight tumors.

To make the discovery, researcher Daniel H. Conrad (Virginia Commonwealth University) and colleagues worked with two groups of mice. The first group of mice was infected with rodent intestinal helminths to stimulate a strong allergic response. Then they were injected with myeloid derived suppressor cells and treated with anti-histamines (cetirizine or cimetidine). Conrad said the treatment with anti-histamines reversed the effects of the myeloid derived suppressor cells.

The second group of mice had tumors and were injected with myeloid derived suppressor cells and treated with the antihistamine, cimetidine. In this group, the antihistamine also reversed the enhanced tumor growth normally seen with myeloid derived suppressor cell injection.

Finally, the scientists examined blood from humans with allergy symptoms (typically associated with increased histamine release). The scientists found that these patients had increased circulating myeloid derived suppressor cells over non-allergic controls.

“This research is very exciting,” said Conrad, “[but] it’s important to realize that this connection is very novel and more research is needed before we know if antihistamines can be used effectively in cancer therapies.”

“We still have much to learn about their potential benefits,” added John Wherry, Deputy Editor of the Journal of Leukocyte Biology. “It is certainly not yet time to prophylactically administer antihistamines for cancer prevention, but the more we learn about myeloid derived suppressor cells, the more interesting these cells and their products become as immunotherapy targets in cancer. These new results suggest that we must be open-minded about seemingly distantly related immune mechanisms.”

Related:
Discuss this article in our forum
Tap water implicated in rise of food allergies
More evidence for opiates role in cancer growth
Immune system ruse nixes peanut allergy
Revealing cancer’s deep evolutionary roots

Source: Federation of American Societies for Experimental Biology

, ,

Comments are closed.
Vtg Kids Flip Book Schering Drug Corp Advertising Demazin Antihistamine 1971
$14.99 Vtg Kids Flip Book Schering Drug Corp Advertising Demazin Antihistamine 1971 picture
Vintage St. Joseph’s Aspirin and Dristan Antihistamine Tin Lot of 2 Tins
$18.0 Vintage St. Joseph’s Aspirin and Dristan Antihistamine Tin Lot of 2 Tins picture
GNP Childrens Allergy Antihistamine 12.5mg diphenhydramine HCI, Cherry 4 oz
$6.41 GNP Childrens Allergy Antihistamine 12.5mg diphenhydramine HCI, Cherry 4 oz picture
Old Vintage Actifed Antihistamine Advertising Pharmaceutical Neck Scarf 44"
$28.99 Old Vintage Actifed Antihistamine Advertising Pharmaceutical Neck Scarf 44
CHILDRENS CLARITIN ALLERGY LORATADINE ORAL 5MG/5ML ANTIHISTAMINE EXP 6/20 L118
$7.99 CHILDRENS CLARITIN ALLERGY LORATADINE ORAL 5MG/5ML ANTIHISTAMINE EXP 6/20 L118 picture

Powered by WordPress. Designed by WooThemes