Broadly effective antibodies against HIV isolated

Researchers working under the auspices of the International AIDS Vaccine Initiative (IAVI) have reported the isolation of 17 novel antibodies capable of neutralizing a broad spectrum of variants of HIV. Founded in 1996, The IAVI is a global not-for-profit organization whose mission is to ensure the development of safe, effective, accessible, preventive HIV vaccines for use throughout the world.

The new broadly neutralizing antibodies (bNAbs), isolated from four HIV-positive individuals, are large protein molecules that bind to pathogens and flag them for destruction. Some of the new bNAbs blocked HIV infection of cells as much as 10 to 100 times as potently as previously discovered bNAbs.

“Most antiviral vaccines depend on stimulating the antibody response to work effectively,” said Dennis Burton, director of the IAVI Neutralizing Antibody Center at The Scripps Research Institute. “Because of HIV’s remarkable variability, an effective HIV vaccine will probably have to elicit broadly neutralizing antibodies. This is why we expect that these new antibodies will prove to be valuable assets to the field of AIDS vaccine research.”

Previous animal studies have suggested that bNAbs could block HIV infection if they were elicited by a preventive vaccine. Researchers expect that they can use information about how bNAbs bind to HIV to construct immunogens – the active ingredients of vaccines – that elicit similar antibodies. The potency of bNAbs matter because a highly potent antibody could confer such protection at relatively low levels.

In that regard, the new bNAbs are very promising as many of them bind hitherto unknown molecular structures on the surface of HIV. This means that they could significantly broaden the target options researchers have in designing vaccines to elicit similar antibodies.

Analysis of the new antibodies also offers some clues as to how future vaccines ought to be formulated to maximize their effectiveness. The authors of the report conclude that AIDS vaccine candidates that seek to effectively harness the antibody response should probably attempt to elicit certain combinations of bNAbs if they are to provide truly comprehensive protection from HIV.

“Solving the neutralizing antibody problem is perhaps the greatest challenge facing the field today,” said IAVI’s chief scientific officer, Wayne Koff. “IAVI concluded many years ago that unlocking the information stored in bNAbs was going to be essential to the fulfillment of our mission – ensuring the design and development of broadly effective AIDS vaccines. We have no doubt that these new bNAbs will contribute a great deal to our own immunogen design efforts and, we hope, those of other researchers working on AIDS vaccines.”

Related:
HIV’s Virulence An Evolutionary Accident
New Study Slams Male Circumcision As HIV Preventative
HIV Prevention Message Failing

Source: International AIDS Vaccine Initiative

, ,

Comments are closed.

DIGIMON TCG X Antibody Proto Form EX5-070 SR (Alternate Art) picture

DIGIMON TCG X Antibody Proto Form EX5-070 SR (Alternate Art)

$25.00



 ** Digimon Digital Monster Digivice Pendulum X Ver 3 Antibody Evolution Blue picture

** Digimon Digital Monster Digivice Pendulum X Ver 3 Antibody Evolution Blue

$169.99



1995 SkyBox Bill Nye The Science Guy Antibodies #20 picture

1995 SkyBox Bill Nye The Science Guy Antibodies #20

$1.99



FIGURE-RISE STANDARD AMPLIFIED OMNIMON (X ANTIBODY) Model Kit USA Seller picture

FIGURE-RISE STANDARD AMPLIFIED OMNIMON (X ANTIBODY) Model Kit USA Seller

$62.99



 ** Digimon Digital Monster Digivice Pendulum X Ver 3 Antibody Evolution Yellow picture

** Digimon Digital Monster Digivice Pendulum X Ver 3 Antibody Evolution Yellow

$140.00



Digimon TCG EX5 Animal Colosseum - Leopardmon X Antibody EX5-043 SR picture

Digimon TCG EX5 Animal Colosseum - Leopardmon X Antibody EX5-043 SR

$4.95



Digimon TCG EX5 Animal Colosseum - MetalGarurumon X Antibody EX5-026 SR picture

Digimon TCG EX5 Animal Colosseum - MetalGarurumon X Antibody EX5-026 SR

$7.95



7/1973 PUB TRW SYSTEMS EPSTEIN BARR VIRUS ANTIBODIES CANCER ORIGINAL EPA AD picture

7/1973 PUB TRW SYSTEMS EPSTEIN BARR VIRUS ANTIBODIES CANCER ORIGINAL EPA AD

$10.83



(free shipping)Pendulum X ver 1.0 Antibody Indicator Black Blue Bandai Digimon picture

(free shipping)Pendulum X ver 1.0 Antibody Indicator Black Blue Bandai Digimon

$277.00



Bandai Original Anime Digimon Adventure War Greymon Dukemon Action Figure Toy picture

Bandai Original Anime Digimon Adventure War Greymon Dukemon Action Figure Toy

$79.79



Powered by WordPress. Designed by WooThemes