2 August 2010
Surgery linked to Creutzfeldt-Jakob disease
by Kate Melville
A Spanish study has found a significant correlation between the risk of certain neurological diseases such as Creutzfeldt-Jakob disease (CJD) and general surgical procedures. The findings follow on from a separate study that showed that disease causing prions can form when brain tissue is exposed to iron.
"Based on the monitoring records of spongiform encephalopathy in two Nordic countries, we studied the possibility of transmission of the sporadic form of Creutzfeldt-Jakob disease through general surgery," explains Jes�s de Pedro, main author of the study and head of prion monitoring in patients at the National Epidemiology Centre of the Carlos III Health Institute.
His findings, published in the Journal of Neurology, Neurosurgery & Psychiatry, reveal that, with a few exceptions, the sporadic form of CJD manifests itself around 20 years after having undergone an operation. The study is based on an analysis of computer records of surgeries kept since the early seventies in hospitals in Sweden and Denmark
"While we are not ruling out the idea that intraoperational transfusions may play a secondary part, the data suggest that the disease enters and spreads much more quickly within the central or peripheral nervous system," says De Pedro.
The finding indicates an external cause of neuronal diseases that could be prevented, and, according to De Pedro; "it may signify a shift in our understanding of the nature of neurodegenerative diseases, such as Alzheimer's or Parkinson's."
"We might, therefore, ask ourselves if other types of motor neuron diseases can be transmitted through surgery and be latent for decades, such as those where risk factors, particularly physical professions and activities or certain sporting activities, for example, which are more likely to lead to surgery, have already been indicated," he added.
Source: Spanish Foundation for Science and Technology