The unexpected discovery of a new type of genetic variation suggests that natural selection – the force that drives evolution – is both more powerful and more complex than scientists had previously thought. The finding, published inNature, could help explain how some organisms, including bacterial pathogens, maintain high levels of diversity and adapt rapidly to new stresses, such as antibiotics.
“We have discovered that natural selection can act not only on whole organisms and individual genes, but also on gene networks,” says Vanderbilt University’s Antonis Rokas, senior author of the paper. Rokas, working with colleagues at the University of Colorado School of Medicine and the Universidade Nova de Lisboa in Portugal, found that a close relative of brewer’s yeast, Saccharomyces kudriavzevii, exists in two very different states: one that can efficiently digest the sugar galactose and one that cannot. Galactose is a natural sugar found in milk and many fruits and legumes. The variant found in Portugal that consumes galactose uses a network of six genes to convert the sugar into energy. What is surprising is the fact that a variant found in Japan that cannot process galactose has nevertheless preserved a non-functional version of the network of galactose genes for millions of years.
“This level of genetic divergence is normal between distantly related species, like human and mouse. Instead, we find it being maintained within a single species of yeast,” the researchers note.
Normally, natural selection and recombination work jointly within an individual species to actively maintain a single version of the genes that perform critical functions or that give organisms a competitive advantage. However, this has not happened with the galactose genes in S. kudriavzevii. When the scientists compared the genomes of the Japanese and Portuguese populations of the yeast, they were surprised to find that the divergence between the galactose genes was a hundred times greater than the divergence between the two genomes as a whole. This indicates that the two states have co-existed for millions of years, which the scientists conclude is convincing evidence that the two have been actively maintained by natural selection.
There is one type of natural selection, called balancing selection, which actively maintains different versions of an individual gene in the gene pool of a population. The classic example is sickle cell anemia. Individuals who inherit the sickle cell variant of the hemoglobin gene from both parents have impaired red blood cells and shortened life expectancy. However, those who receive a sickle cell gene and a normal hemoglobin gene have an increased resistance to the parasite that carries malaria, giving them an advantage wherever malaria is present.
A number of scientists are looking for examples of balancing selection, but they are focused on single genes. Until researchers begin looking for this type of selection, it is not possible to determine whether it is a rarity or a fundamental process. One place to look for this new form of selection is among pathogens, many of which have lifestyles very similar to that of yeast: They have very large populations and self-fertilize most of the time, reserving sexual reproduction for periods of high stress. Selection acts most powerfully in large populations and self-mating makes it easier to maintain alternative states that are difficult to sustain.
If this new type of selection is providing a competitive advantage to even one human pathogen, identifying it could prove important. “We are currently in a war with pathogens and we are loosing the battle. So every advantage we can get in understanding how pathogens adapt could be significant,” says Rokas.
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