Ink Delivers DNA

The journal Genetic Vaccines and Therapy reports that German researchers have found tattooing to be an extremely effective method for delivering DNA vaccines. “Vaccination with naked DNA has been hampered by its low efficiency,” said Martin Müller, of the German Cancer Research Center. “Delivery of DNA via tattooing could be a way for a more widespread commercial application of DNA vaccines.”

Using a coat protein from the human papillomavirus as a model DNA vaccine antigen, they compared delivery by tattooing the skin of mice against standard intramuscular injection with, and without, the molecular adjuvants that are often given to boost immune response.

Müller found that the tattoo method gave a stronger humoral (antibody) response and cellular response than intramuscular injection, even when adjuvants were included in the latter. Three doses of DNA vaccine given by tattooing produced at least 16 times higher antibody levels than three intramuscular injections with adjuvant. The adjuvants enhanced the effect of intramuscular injection, but not of tattooing.

Müller explained that tattooing provokes inflammation which “primes” the immune system. Additionally, tattooing covers a bigger area of the skin than an injection, so the DNA vaccine can enter more cells. Müller speculates that these effects may account for the stronger immune response. The researchers believe that tattooing could play a role in the routine vaccination of cattle or in delivering therapeutic vaccines to humans.

Related:
Viral-Vector Vaccines Vexed
New Delivery Method For Gene Therapy

Source: BioMed Central

, ,

Comments are closed.

DJEEP Pocket Lighters, TATTOO Collection picture

DJEEP Pocket Lighters, TATTOO Collection

$54.99



Collectible 35” Hookah “Ed Hardy” /complete set /Tattoo Design /Limited Edition picture

Collectible 35” Hookah “Ed Hardy” /complete set /Tattoo Design /Limited Edition

$239.99



Tattoo Glass® THICK Colorful Showerhead Bong ALIEN Glass Water Pipe HOOKAH *USA* picture

Tattoo Glass® THICK Colorful Showerhead Bong ALIEN Glass Water Pipe HOOKAH *USA*

$129.99



Vintage Great Britain Tattoo real postcard 1920s image Unknown man Schiffmacher picture

Vintage Great Britain Tattoo real postcard 1920s image Unknown man Schiffmacher

$22.00



 Voltron: Defender Of The Universe  1984 Topps 36 SEALED Tattoo packs in Box  picture

Voltron: Defender Of The Universe 1984 Topps 36 SEALED Tattoo packs in Box

$65.00



PEE WEE’S (HERMAN)  PLAYHOUSE TATTOO SHEET SET OF 12 - RARE picture

PEE WEE’S (HERMAN) PLAYHOUSE TATTOO SHEET SET OF 12 - RARE

$8.00



50pcs random Vintage Pinup girls, Tattoo Girls Stickers picture

50pcs random Vintage Pinup girls, Tattoo Girls Stickers

$4.00



💫DUTCH Bros STICKER Tattoos Sticker Hunt RARE YOU PICK 💫🖖 picture

💫DUTCH Bros STICKER Tattoos Sticker Hunt RARE YOU PICK 💫🖖

$6.00



Blink Torch Display - Tattoo Theme - (4ct) picture

Blink Torch Display - Tattoo Theme - (4ct)

$10.99



Titans #1 Nathan Szerdy Tattoo Virgin Foil B Variant CGC 9.8 picture

Titans #1 Nathan Szerdy Tattoo Virgin Foil B Variant CGC 9.8

$79.99



Powered by WordPress. Designed by WooThemes