Lactic Acid Not The Culprit In Muscle Fatigue

Scientists at La Trobe University in Melbourne and at the University of Aarhus in Denmark have discovered the mechanism by which acidity helps prevent muscle fatigue. Their discovery overturns the previously held belief among physiologists and athletes that acidity, through a build up of lactic acid, is a major cause of muscle fatigue.

The research, by Professors George Stephenson and Graham Lamb in Australia and Mr Thomas Pedersen and Professor Ole Nielsen from Denmark, appeared in the journal of the American Association for the Advancement of Science.

The researchers carried out their project using a technique in which the surface membrane of single muscle fibres – which are half the thickness of a human hair – is peeled away, without interfering with the ability of the muscle fibre to contract normally to electrical stimulation. This enabled the researchers to change conditions inside the muscle cells and study the effects of acidity on the force response.

“We found that muscles play a clever trick in which they use acidosis – the build-up of acid – to help ensure that they keep responding properly to nerve signals and so avoid the fatigue that would otherwise occur,” said Lamb.

Muscle contraction in a skeletal muscle fibre in response to a nerve impulse is the result of a complex series of events known as excitation-contraction-coupling. There is a network of tiny tubes in muscle fibre known as the T-system that allow electrical signals, set up on the muscle fibre’s surface in response to nerve signals, to move deep inside and excite the whole of the fibre.

“Chloride ions play an important role in muscle by dampening the excitability of the surface membrane and T-system, ensuring that they only respond when stimulated by nerve signals and do not become spontaneously excited,” Stephenson said. “When a muscle is worked hard, potassium ions come out of the fibres and make the membrane less excitable. The acidity generated inside a working muscle helps counter this depressing effect by reducing the influence of chloride, which helps the muscle membranes stay excitable. It is a very clever trick because rested muscles need the chloride effect normally to prevent them spontaneously contracting. The acidity produced by the strenuous exercise reduces chloride’s stabilising effect, enabling the impulses to keep exciting the muscle when they would otherwise fail. We have concluded that intracellular acidosis increases the excitability of the T-system, thus counteracting fatigue at a critical step in excitation-contraction-coupling.”

“This finding should be of great interest not only to elite athletes and the many laboratories around the world involved in muscle research,” concluded the researchers.

, ,

Comments are closed.

Vintage 1988 Magic Coffee Mug - Pangaea - Science News Nerds Science Service picture

Vintage 1988 Magic Coffee Mug - Pangaea - Science News Nerds Science Service

$25.19



Science News Letter Magazines Lot of 13 VTG 1932 Weekly Summary Current Science picture

Science News Letter Magazines Lot of 13 VTG 1932 Weekly Summary Current Science

$40.45



2009 Fall Issue of American Legacy Magazine With MUHAMMAD ALI - picture

2009 Fall Issue of American Legacy Magazine With MUHAMMAD ALI -

$14.95



Science News Letter Magazines Lot of 13 VTG 1934 Weekly Summary Current Science picture

Science News Letter Magazines Lot of 13 VTG 1934 Weekly Summary Current Science

$40.45



SCIENCE FACT DOG SNIFFING CAN GET MORE FACTS ANTI FOX NEWS10X4 WVPO-0627 STICKER picture

SCIENCE FACT DOG SNIFFING CAN GET MORE FACTS ANTI FOX NEWS10X4 WVPO-0627 STICKER

$3.49



1938 Science Bldg Box Elder High School Brigham City Utah Original News Photo picture

1938 Science Bldg Box Elder High School Brigham City Utah Original News Photo

$14.99



1962 Press Photo Walter Sullivan, Science News editor of The New York Times picture

1962 Press Photo Walter Sullivan, Science News editor of The New York Times

$19.99



crp-31 news photo computer science in 1960 John M Cladwell Mechosapien thinking picture

crp-31 news photo computer science in 1960 John M Cladwell Mechosapien thinking

$9.99



Science News Letter Magazines Lot of 10 VTG 1936 Weekly Summary Current Science picture

Science News Letter Magazines Lot of 10 VTG 1936 Weekly Summary Current Science

$33.15



Science News Letter Magazines Lot of 6 VTG 1935 Weekly Summary Current Science picture

Science News Letter Magazines Lot of 6 VTG 1935 Weekly Summary Current Science

$21.85



Powered by WordPress. Designed by WooThemes