Stem Cell Research - 05/25/05 01:30 PM
The idea that embryonic stem cell research promises miracle cures not available from adult stem cell research is old science. It is based on the idea that cells once differentiated are fixed and cannot be reset back to pluripotency or totipotency. Over the past 30 years more and more discoveries showing that cells can be reprogrammed have occurred. The promise of embryonic stem cell therapy has become largely a matter of popular superstion no longer supported by real science. There is an important role for embryonic stem cell research. By studying them, we can learn how to reprogram adult stem cells. This is the only valid role for embryonic research today. There is no valid expectation of important clinical therapies using embryonic stem cells.
There are major systemic problems with embryonic stem cell therapy which do not exist with adult stem cell therapy. These originate with the immune system and rejection of foreign materials. Therapeutic cloning is supposed to be the miracle solution for this problem. However, it introduce two new and significant kinds of risk for a patient which do not exist with adult stem cell therapy. 1) The cloning process itself runs the risk of altering the DNA, or subtle factors like the methylization of DNA, thus causing unpredictable disorders in the patient. 2) The clone is a genetic chimera containing the mitochondrial dna of the egg and the nuclear dna of the patient. Modern discoveries have shown that mitochondrial dna is more active and plays a larger role in metabolism than previously though. How that chimera will work in the body is unknown and potentially the source of many new and unknown disorders. None of these roadblocks exist with adult stem cell therapy.
The role of embryonic stem cell research is very narrow and does not include actual therapy on real patients. It has a role in the laboratory to help isolate the factors which allow the reprogramming of adult stem cells. It is basically useless for clinical therapy.
http://www.dw-world.de/dw/article/0,1564,1515236,00.html#
There are three reasons why people persist in the basically superstitious belief in miracles from embryonic stem cell therapy. 1) Some scientists have spent their lives on it and find it hard to realize that they have spent their lives following a dead end. 2) Some political groups have used it to further their own political agenda and find it difficult to realize that they have deluded themselves and their followers. 3) Desperate people will believe anything if it gives them hope of a cure, no matter how farfetched or unrealistic it may be.
The third reason is both sad and ugly. A couple of years ago some medical hotshots in Florida wanting more organs for transplant introduced a program for handling injured young adults which essentially killed them in order to harvest their organs. This was discovered, and some conscientious proponents of organ donation objected. After doing so they found themselves subjected to hatred by people who up to then had been their friends. Many people with desperate medical conditions or with loved ones with desperate medical conditions are willing to do anything for a cure. Even murder you or me in cold blood.
In a way the faith in embryonic stem cell therapy is the modern equivalent of faith in human sacrifice. It makes a kind of emotional sense to believe that if you take the life of a pure perfect infant before it has differentiated its magical life force will cure your disease. It is the same psychology which has traditionally made 4 year old boys the favorite candidates for human sacrifice. A practice that continues in some parts of East Africa today and which has resulted in at least one ritual murder in London.
It is sad, absurd, and ugly. Desperate people do desperate things and they do not really respect the right to life of others. Desperation destroys their reason.
There are major systemic problems with embryonic stem cell therapy which do not exist with adult stem cell therapy. These originate with the immune system and rejection of foreign materials. Therapeutic cloning is supposed to be the miracle solution for this problem. However, it introduce two new and significant kinds of risk for a patient which do not exist with adult stem cell therapy. 1) The cloning process itself runs the risk of altering the DNA, or subtle factors like the methylization of DNA, thus causing unpredictable disorders in the patient. 2) The clone is a genetic chimera containing the mitochondrial dna of the egg and the nuclear dna of the patient. Modern discoveries have shown that mitochondrial dna is more active and plays a larger role in metabolism than previously though. How that chimera will work in the body is unknown and potentially the source of many new and unknown disorders. None of these roadblocks exist with adult stem cell therapy.
The role of embryonic stem cell research is very narrow and does not include actual therapy on real patients. It has a role in the laboratory to help isolate the factors which allow the reprogramming of adult stem cells. It is basically useless for clinical therapy.
http://www.dw-world.de/dw/article/0,1564,1515236,00.html#
There are three reasons why people persist in the basically superstitious belief in miracles from embryonic stem cell therapy. 1) Some scientists have spent their lives on it and find it hard to realize that they have spent their lives following a dead end. 2) Some political groups have used it to further their own political agenda and find it difficult to realize that they have deluded themselves and their followers. 3) Desperate people will believe anything if it gives them hope of a cure, no matter how farfetched or unrealistic it may be.
The third reason is both sad and ugly. A couple of years ago some medical hotshots in Florida wanting more organs for transplant introduced a program for handling injured young adults which essentially killed them in order to harvest their organs. This was discovered, and some conscientious proponents of organ donation objected. After doing so they found themselves subjected to hatred by people who up to then had been their friends. Many people with desperate medical conditions or with loved ones with desperate medical conditions are willing to do anything for a cure. Even murder you or me in cold blood.
In a way the faith in embryonic stem cell therapy is the modern equivalent of faith in human sacrifice. It makes a kind of emotional sense to believe that if you take the life of a pure perfect infant before it has differentiated its magical life force will cure your disease. It is the same psychology which has traditionally made 4 year old boys the favorite candidates for human sacrifice. A practice that continues in some parts of East Africa today and which has resulted in at least one ritual murder in London.
It is sad, absurd, and ugly. Desperate people do desperate things and they do not really respect the right to life of others. Desperation destroys their reason.